ABSTRACT
Background: Stroke is a leading cause of death and disability worldwide acute ischaemic stroke accounts for 87% of strokes and mostly affects persons at the peak of their lives. Magnesium is known to have neuroprotective effects in ischemic stroke through a variety of mechanisms including decrease in glutamate release and inhibition of NMDA receptors and vasodilation. Previous studies on serum magnesium levels in stroke patients have shown variable results with many of them finding lower levels than in normal subjects. This study was undertaken to compare serum magnesium levels in patients of acute ischemic stroke with those of controls and also find a correlation if any between serum magnesium levels and neurological disability.Methods: This was a prospective non-interventional case-control study in which 50 patients of acute ischemic stroke in the age group of 20 to 80 years admitted in the department of Medicine Government Medical College Jammu from October 2019 to January 2020 were taken. Their serum magnesium levels were analysed within first 24 hours of admission and neurological disability was measured using modified Rankin Score. Serum magnesium levels were also estimated in 35 healthy controls for comparison.Results: Serum magnesium was lower in the study group (mean of 1.85±0.36) as compared to the control group (mean of 2.4±0.21) which was statistically significant (p value =0.001). Modified Rankin Score was 4 to 5 in 27 patients and 2 to 3 in 23 patients and it was negatively correlated with serum magnesium levels (r =-0.67).Conclusions: Ischemic stroke patients had lower serum magnesium levels as compared to healthy subjects in our study and also lower levels were seen in those with higher neurological disability.
ABSTRACT
Introduction: Diagnosis of carpal tunnel syndrome (CTS)is based on clinical symptoms, examination findings, andelectrodiagnostic studies. Recent studies have shown theefficacy of median sensory-ulnar motor latency differencewas devised as another way to improve diagnostic accuracyfor mild carpal tunnel syndrome. Current research aimed tostudy diagnostic value of Median sensory ulnar motor latencydifference (MSUMLD) in mild carpal tunnel syndromeand compare it with median-ulnar (MU) sensory and motorlatency differences.Material and methods: 100 hands of CTS were studied andafter a detailed history and physical examination, routine testsand nerve conduction study was done .In mild CTS cases notdetected by routine NCS, MSUMLD was calculated and itssensitivity was compared with MU sensory and motor latencydifference.Results: It was found that Median Ulnar sensory latencydifference had the highest sensitivity.Conclusion: MSUMLD can be added as a new diagnosticparameter in detecting mild CTS with no additional testingalthough it’s sensitivity is less than Median-Ulnar sensorylatency difference